- Ischemic strokes occur when there is blocked blood flow to the brain.
- Certain medications can be used to dissolve blood clots causing ischemic strokes.
- A recent paper indicates that tenecteplase may have superior functional outcomes than alteplase.
A systematic review published in Neurology compared tenecteplase and alteplase, finding that tenecteplase is associated with better recovery and less disability three months post-stroke.
Tenecteplase vs Alteplase: How Do They Compare?
Timely administration of these clot-busting drugs is crucial. While alteplase is the only FDA-approved treatment for acute ischemic stroke, tenecteplase has been recommended in some regions.
The study analyzed data from 3,788 participants treated with tenecteplase and 3,757 with alteplase. Results revealed that those receiving tenecteplase had better functional outcomes compared to those on alteplase.
Clinical Implications
This research indicates that transitioning to tenecteplase could enhance patient outcomes and streamline care due to its easier administration.
Regulatory Status
Though tenecteplase is approved for heart attacks, it currently lacks FDA approval specifically for stroke treatment, necessitating further research.
